The value of Magnetoencephalography (MEG) in detecting and localizing focal interictal epileptiform discharges (IEDs) in epilepsy patients is undisputed. However, current cryogenic MEG systems present limitations, particularly for pediatric patients, due to their rigid helmet design. In this episode, we discuss these challenges and potential solutions with Dr. Feys, whose research focuses on on-scalp MEG technology using optically pumped magnetometers (OPMs).

Dr. Feys' team conducted a single-center study on school-aged children with either self-limited idiopathic or refractory focal epilepsy. The researchers compared IED detection and localization using traditional cryogenic MEG and the new on-scalp MEG method. Their results showed that the on-scalp MEG provided higher IED amplitudes, a better signal-to-noise ratio, and similar localizatio ...