Transcranial magnetic stimulation (TMS) is emerging as an innovative treatment for a range of psychiatric disorders, but the current methods for identifying stimulation targets could be improved. In this episode, we are joined by Dr. Balderston, who discusses his pioneering work on a novel targeting optimization approach for TMS treatments that combines whole-brain resting state functional connectivity (rsFC) and electric-field (e-field) modeling.

Dr. Balderston explains how this approach allows for more personalized, symptom-specific TMS targets. He shares results from a proof of concept study involving 91 anxious misery (AM) patients and 25 controls. Using principal component analysis (PCA) regression, his team predicted symptoms from rsFC and estimated the parameter vector for the e-field augmented model.

The potential applications ...