In this episode of Atomically Speaking, NENSC Co-Chair Daniel Poneman sits down with Dr. Stephen Streiffer to discuss the legacy of the Manhattan Project and how it continues to shape the Oak Ridge National Laboratory’s mission today. Dr. Streiffer walks through the history of uranium enrichment and the technologies used over the years, from the gaseous diffusion process and electromagnetic separation to laser isotope separation technologies now being studied for potential commercial energy applications. He also discusses Oak Ridge National Laboratory’s current priorities and the role it plays in supporting the May 2025 White House Executive Orders aimed at restoring U.S. nuclear leadership, including the DOE Genesis Mission — a national initiative to accelerate scientific discovery through the use of artificial intelligence.