PHARM | 1st Gen Cephalosporins (Cephalexin)

STAT Stitch Deep Dive Podcast Beyond The Bedside by Regular Guy

Episode notes

This is everything 1st Gen Ceph Drugs. For my RN Program this class includes Cephalexin.

First-Generation Cephalosporins

Examples: Cefadroxil, Cefazolin, Cephalexin Class: Anti-infective | Pharmacologic: Cephalosporin (1st Gen) MOA: Binds to bacterial cell-wall membrane → cell death (bactericidal).

Top Indications

1️⃣ Skin & soft-tissue infections. 2️⃣ UTIs. 💉 Cefazolin: peri-operative surgical prophylaxis.

Therapeutic Effect

Resolution of infection — ↓ redness, swelling, discharge, pain, fever.

Contraindications / Cautions

  • Allergy: Cephalosporin or serious PCN reaction → risk of anaphylaxis.
  • Rena ... 
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