In this episode, we step inside the ambulance to explore a question rarely discussed: how safe is the air paramedics breathe when administering methoxyflurane, marketed as Penthrox. While not used in the United States, Penthrox is widely used in Australia and other parts of the world as an inhaled analgesic for prehospital pain management. In this month’s journal club, we unpack a controlled laboratory study that measured occupational exposure inside ambulance environments, examine how ventilation changes the equation, and discuss what the findings mean for paramedic safety, system design, and the evolving balance between patient comfort and clinician health. A thoughtful ride through science, safety, and real-world EMS practice.