Dr. Jessica Pelletier and Noah Kronk speak with Dr. Stephen Liang, an emergency medicine physician and infectious disease expert, about the diagnosis and management of mpox in the ED setting.

Take-Home Points:

• Two clades:
  • Clade 1 (Central Africa): classic, more severe disease
  • Clade 2 (West Africa): subtle, non-classic presentations including genital/anal lesions and proctitis in the 2022 global outbreak
• Transmitted via exposure to body fluids, skin lesions, or respiratory secretions
• Incubation period: 5-14 days
• Lesions can mimic a wide range of diseases - keep a broad differential, including other sexually transmitted infections in the right context
• For most patients, care is supportive
• Those with or at high risk for severe disease should receive tecovirimat