Deciphering Osteosarcopenia: Aging, Muscle Loss, and Bone Fragility

In this episode of Talking Healthspan, we dive deep into osteosarcopenia, a condition that combines muscle loss (sarcopenia) and bone loss (osteopenia/osteoporosis), which significantly impacts the health of older adults. As we continue to understand aging and its effects on the body, the rise of osteosarcopenia as a critical factor in functional decline, falls, and fractures requires urgent attention. This episode explores how aging mechanisms drive this condition and what science is doing to combat it.

We use the Hallmarks of Aging framework—an insightful way to break down the biological processes behind aging—to explain how bone and muscle deteriorate together. You’ll hear about the key mechanisms like genomic instability, telomere attrition, and chronic ...