Episode notes
In this session from the 12th Annual Update Course in Pediatric Surgery, Dr. Bhargava Mullapudi (Children’s Mercy Kansas City) presents updated strategies in Wilms tumor management, exploring how tumor biology and global guidelines are shaping decisions on surgery vs chemotherapy first.
Key Highlights:
- COG vs SIOP Guidelines: North American centers (COG) typically favor primary surgery, while European protocols (SIOP) begin with chemotherapy—highlighting major global practice differences.
- Impact of Tumor Genetics: Loss of heterozygosity (LOH) at chromosomes 1p and 16q, as well as gain of 1q, influence chemotherapy decisions even in lower-stage disease.
- Staging and Size Aren’t Enough: While age and tumor weight are considered, biological markers ultimately guide treatment, challenging simplified “under 2 years / un ...
Keywords
update coursepediatric surgerysurgeryupdate course rewindsome4pedsurgpedsurgupdate course 2024wilms tumorwilms tumor managementtumor biologysurgery firstchemotherapychemotherapy firstchromosomes1p16qheterozygositytumor geneticstumor weightLOHloss of heterozygositystage 1 tumorschildren's Oncology group