Prior vaccination prevents overactivation of innate immune responses during COVID-19breakthrough infection

DOI: 10.1126/scitranslmed.adq1086

Central Idea: This study examines how previous COVID-19 vaccination influences both innate and adaptive immune responses during breakthrough infections. The researchers found that vaccination helps prevent excessive activation of the immune system, particularly in innate immune cells like monocytes and natural killer (NK) cells.

Key Concepts:

1. Breakthrough vs Primary Infections:

• Breakthrough infections = COVID infections in vaccinated people
• Primary infections = COVID infections in unvaccinated people
• Study focused on Delta variant period (April-December 2021)

2. Immune Response Differences:

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