Episode notes
DOI: 10.1038/s41586-024-08173-7
Central Idea: This paper presents a modular autonomous chemical synthesis platform integrating mobile robots, a Chemspeed ISynth synthesizer, UPLC-MS, and benchtop NMR, enabling automated experimentation and heuristic decision-making for exploratory synthesis. This approach mimics human workflows by using orthogonal characterization data and is applicable to diverse chemical challenges, including structural diversification, supramolecular assembly discovery, and photochemical synthesis.
Key Concepts:
Autonomous vs. Automated Synthesis: The paper distinguishes between automated experiments (researcher-driven decisio ...