Episode notes

Review: The Hallmarks of Cancer Immune Evasion

DOI: 10.1016/j.ccell.2024.09.010

Claudia Galassi, Timothy A. Chan, Ilio Vitale & Lorenzo Galluzzi

Central Idea: This review proposes a "Three Cs" framework (Camouflage, Coercion, and Cytoprotection) to categorize the diverse mechanisms cancer cells utilize to evade the immune system.

Key Concepts:

  • Camouflage: Hiding from immune detection.
    • Downregulation of MHC class I molecules and/or associated proteins (e.g., B2M, TAP1/2).
    • Epigenetic silencing of MHC and antigen processing genes.
    • Impaired chemoattraction through altered ATP, ANXA1, and ... 
 ...  Read more