ITPRIPL1 binds CD3ε to impede T cell activation and enable tumor immune evasion

Science TLDR by Raymond Ruff

E04
14:54
Episode notes

This episode delves into a fascinating study that uncovers a novel immune checkpoint molecule, ITPRIPL1, and its role in suppressing T cell activation and enabling tumor immune evasion.

Key Findings:

  • ITPRIPL1, a protein normally enriched in the testes, is overexpressed in various human cancers, particularly those with low or no PD-L1 expression.
  • ITPRIPL1 directly binds to CD3ε, a component of the T cell receptor complex, and inhibits downstream signaling pathways, ultimately impeding T cell activation and function.
  • ITPRIPL1 knockout mice exhibit increased T cell infiltration in the testes, suggesting its role in maintaining immune privilege.
  • A neutralizing antibody targeting ITPRIPL1 effectively reverses T cell suppression in vitro and inhibits tumor growth in vivo by prom ... 
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