Nootropics Depot leads the supplement industry through expertly formulated products, tested in our world-class lab. Learn about the creativity behind Nootropics Depot's products, and the history behind the botanicals that keep us healthy and well in Nootropics Depot's monthly podcast.
Tribugen | How We Took Tribulus To The Next Level Tribulus Terrestris is a powerful supplement that boosts energy, motivation, and vitality! This month, Emiel and Erika discuss how Nootropics Depot took Tribulus Terrestris to the next level with Tribugen, our optimized stack that combines Tribulus with Mung Bean, Cordyceps, Dioscorea nipponica, and Fenugreek. Each ingredient in Tribugen was selected to compliment the stimulating and motivating effects of Tribulus, and in this episode Emiel discusses the mechanisms of action that are responsible for these effects. Before Tribugen made it’s debut, the team at Nootropics Depot tried a variety of Tribulus Terrestris extracts to find the most motivating but smooth extract that would shine as a stand-alone product. When making Tribugen, we wanted to increase the motivation benefits of Tribulus, but to smooth out the stimulation and edginess of Tribulus when taken on its own. After a year of bioassaying Tribugen, adjusting the dosages of the synergistic ingredients, and sharing the pre-released stack with friends, family and colleagues, we arrived at the finished product. If you are interested in learning more about this process, and the ingredients that make up the Tribugen stack, tune into this podcast episode on your favorite streaming platform! Podcast Chapters 0:00 Introduction 3:06 Mega-Dosing Tribugen 6:07 Making A Next-Level Tribulus Terrestris Extract 8:45 Why Do People Reach for Tribulus? 17:00 Where Do We Source Our Tribulus Terrestris? 18:40 β-carbolines - Monoamine Oxidase Inhibitors 21:00 Connecting Pharmacodynamics with Perceptible Benefits 24:00 Creating the Tribugen Stack 32:00 Taking Tribulus with Vignatex 34:00 How Cordyceps Interacts Within the Tribugen Stack 35:29 Cordyceps + Caffeine Connection 40:30 Choosing Synergistic Compounds + Dosages 58:30 Protodioscin + Diosgenin 1:05:19 DHEA 1:08:00 Focus Enhancing Effects of Tribugen 1:09:00 Stimulation Effects of Tribugen 1:21:00 Conclusion
March Mushroom Magic | Energy, Focus and Motivation From Your Daily Dose of Adaptogenic Mushrooms Have you experienced the mood lifting, physically relaxing, cognition enhancing benefits of adaptogenic mushrooms? Listen to our new podcast episode as we review Nootropics Depot's new Mushroom Magic drink mixes! Emiel and Erika disucss how Nootropics Depot sources coffee, matcha and cocoa for the most delicious drinking experience, and why Mushroom Magic drinks are great to share with friends and family! Learn more about why we chose Lions Mane, Cordyceps, Tiger Milk and Poria mushroom for our blend of gut health boosting, energizing, and immune supporting drink mixes. Learn More About Lions Mane and Tiger Milk Mushrooms Lion’s Mane Mushroom | The Journey To Connect Modern Science With Traditional Chinese Medicine Tiger Milk | Could It Be The New Lion's Mane? | This Rare Malaysian Mushroom Is Finally On The Prowl Follow Us on Instagram Podcast Chapters 00:00 Introduction 00:40 Introducing Mushroom Magic Drink Mixes 1:02 Gut Function and Microbiome 1:45 Beta Glucans and Polysaccharides Benefit Our Gut 3:45 Follow Us On Instagram @insearchofinsight 5:20 Poria Mushroom Sclerotium 6:25 Check Out Emiel’s Updated Stack on Reddit 8:15 Unextracted Mushrooms Contain More Beta Glucans 9:00 500 Milligrams of Poria, Lion’s Mane, Cordyceps, and 150 mg Tiger Milk 11:20 Why Mushroom Magic Drinks Contain SCOOPS 19:35 Drinking Mushroom Magic Matcha - iced latte with milk 25:20 Stevia - Why We Sourced a Higher Quality Stevia 28:00 Perceptible Effects of Mushroom Magic Matcha 31:50 Our Matcha vs. Traditional Matcha Teas 34:50 Ceremonial Grade Matcha 38:05 Effects of Poria and Tiger Milk sclerotium 49:25 Checking in On the Perceptible Benefits 56:39 The Difference Between Caffeine and Mushrooms in Isolation vs. Mushroom Magic mixes 58:05 Beta Testing Mushroom Magic drinks with friends, family and coworkers 1:07:30 Drinking Mushroom Magic Coffee 1:20:43 Non-Perceptible Benefits of Adaptogenic Mushrooms 1:26:29 Drinking Mushroom Magic Cocoa 1:39:38 Cordyceps Mushroom Health Benefits 2:08:30 Drinking Mushroom Magic Coffee Latte 2:12:40 Mushroom Magic with your Daily Supplement Stack 2:14:20 Be Moderate When Taking Multiple Doses of PreBiotics - Digestion 2:19:00 Coffee Approved By Coffee Nerds (Emiel and Erika) 2:20:30 Closing Remarks on Perceptible Benefits of Mushroom Magic Drinks
Your Body’s Amazing Immune System | Is It Better To Take A Natural Approach When You Get Sick? Our immune system is our body’s defense against sickness and infection. In this month’s podcast episode, Emiel and Erika discuss inflammation, oxidation, immune supporting supplements, fermented foods, and gut health, and explore ways to stay healthy all year round. This episode is focused on why inflammation and oxidation are essential for helping us fight off pathogens, and therefore, why taking a natural approach when getting sick may help us recover faster. Sometimes, it can be advantageous to lean into the inflammation and oxidation caused by our immune system, though this can be uncomfortable. Dampening inflammation and oxidation can prolong illness, and work against our immune system’s natural response to pathogens. Tune into the new podcast episode to learn more about: How inflammation and oxidation are tools that the immune system uses to attack pathogens and help us recover from illness Why fermented foods and carbohydrates are essential for a healthy immune system Vitamins, minerals, and supplements that support a healthy immune system The connection between the gut and the immune system Why symptom management during illness can work against us, and what to do instead Podcast Chapters 00:00 Introduction - Immune System 01:15 How Does Our Environment Affect Our Immune System? 05:30 Inflammation and Oxidation are Tools of the Immune System 06:45 Taking GABA for Immune Function 17:20 The Impact of Gut Health on the Immune System - Why Kombucha? 18:50 How Lindsay Lohan Ruined The Kombucha Industry 23:40 Stomach Acid is the First Line of Defence Against Viruses and Bacteria 26:44 How Fermentation and Food Preservation Supports Our Immune Function 30:44 Sauerkraut - Low PH Means Bad Bacteria Die, Good Bacteria Live 36:25 Short Chain Fatty Acids - Fibers, prebiotics, and biotics 42:45 How the Immune System Functions Beyond Our Gut 46:05 We Have Microbiomes Everywhere 47:55 Innate vs. Adaptive Immune System 57:30 How Genetics Factor Into Our Immune System Response 1:00:00 Leaning Into the Immune Response 1:09:43 Why Do We Get Fevers When We Get Sick? 1:30:16 Sickness Behavior 1:34:34 How To Boost Immune System When You’re Not Sick 1:54:00 Behavior, Micronutrients, and Mushrooms 2:14:00 How to Take Supplements When Getting Sick 2:18:47 Supplements to Support Your Immune System 2:33:39 GABA for the Gut, Mood, and Immune System 2:36:14 Conclusion
Kanna | Can This South African Succulent Make You a Better Dancer? Kanna is a unique succulent plant, originating from South Africa. It has been used as a mood and energy boosting botanical for thousands of years by the KhoiSan people of South Africa, for dancing ceremonies and as a hunting aid. In this month's podcast episode, Emiel (Nootropics Depot Product Specialist) and Erika discuss the history of Kanna, its pharmacokinetics and mechanisms of action, and how Kanna provides a distinctly uplifting effect from its serotonergic activity. Tune in to learn about dosing Kanna, taking Kanna at night clubs in Amsterdam, mesembrine, mesembrenone, and Delta 7 mesembrenone, and why you should try Kanna for its pro-social benefits. Follow In Search of Insight on Instagram https://www.instagram.com/insearchofinsight?igsh=ZGNjOWZkYTE3MQ%3D%3D&utm_source=qr Buy Full Spectrum Kanna Tablets from Nootropics Depot https://nootropicsdepot.com/full-spectrum-kanna-extract-quick-dissolve-tablets/ Read Nootropics Depot's Blog on Kanna https://nootropicsdepot.com/kanna-lift-mood-and-lower-stress Podcast Chapters 00:00 Introduction 04:10 Dosing Kanna 09:40 Stimulating Effects of Kanna 11:50 Fat or Water Soluble? Bioavailbility of Kanna 17:30 Oral & Sublingual Administration 18:53 Pharmacokinetics - T Max and C Max 34:00 Caffeine Usage and Concentration 36:00 Dynamax Pharmicokinetics 38:45 Mood, Focus, Energizing, Pro-Social Effects of Kanna 43:00 Traditional Uses of Kanna, Amanita Muscaria, Kava 50:00 Neuroscience of Kanna - Neurotransmitter Releaser 53:07 Mesembrine acts as a VMAT2 Upregulator 1:03:40 Testing Mesembrine Content of Kanna Extracts 1:14:10 Cultivars of Kanna - Sceletium tortuosum 1:14:54 What Sets Nootropics Depot’s Kanna Extract Apart 1:18:22 Beta Testing and Initial Bio-assaying 1:25:31 Kanna as a Subtle Appetite Suppresant 1:33:11 Emiel & Erika’s Current Occasional Supplements 1:47:07 Emiel & Erika’s Daily Supplement Stack 1:57:24 Conclusion
Isoliquiritigenin | Candy For Your Brain This month, learn all about neurotransmitters and the powerful mechanisms of action behind Nootropics Depot’s mood-boosting licorice root extract, Isoliquiritigenin. Erika and Emiel take you on a journey through the traditional uses of licorice, what makes it such a soothing remedy for inflammation, and where licorice candy originates from. Buy Isoliquiritigenin from Nootropics Depot https://nootropicsdepot.com/isoliquiritigenin-controlled-dissolve-tablets/ Follow In Search of Insight on Instagram https://instagram.com/insearchofinsight?igshid=MzMyNGUyNmU2YQ%3D%3D&utm_source=qr Podcast Chapters 00:00 Introduction 00:18 Licorice Root 03:53 Isoliquiritigenin 06:07 Mega-Dosing Isoliquiritigenin 10:27 Traditional Uses of Licorice Root 14:23 Why Is Licorice Candy Black? 15:28 Where The Classic Licorice Flavor Came From 24:32 Slight Detour - The Use of Quinine in Tonic Water 28:58 The Medicinal Background of Vermouth, Absinthe, Coca Cola 32:00 Tasting Dutch Licorice 35:12 Ammonium Chloride as a Cough and Mucus Remedy 43:00 Laws Against Licorice 44:54 Tasting Mild Salt Licorice 48:02 Benefits of Licorice Root and Isoliquiritigenin 54:12 The Pharmacology of Isoliquiritigenin 57:36 Neurotransmitter Basics 1:00:38 What Effects are Produced When Norepinephrine, Serotonin, and Dopamine Build Up? 1:02:34 GABA-A and GABA-B Activation 1:06:20 GABA, Amino Acid Neurotransmitter vs. Norepinephrine, Serotonin, and Dopamine Monoamine Neurotransmitter 1:08:19 Why We Typically Try to Dampen Glutamatergic Activity 1:09:40 Glycine, a Neurotransmitter 1:16:17 Dopamine D3 Agonist Effects of Isoliquiritigenin 1:18:38 Isoliquiritigenin For Pain Management 1:20:21 Isoliquiritigenin For Long Term Potentiation 1:22:47 Tonic Water - Traditional and Modern Uses 1:26:32 New Products From Nootropics Depot - Mushroom Magic Matcha 1:31:57 Why Not Ceremonial Grade Matcha? 1:36:55 The Mushroom Blend of Mushroom Magic Matcha 1:46:08 The First Scoop for Nootropics Depot 1:48:48 Full Spectrum Kanna Tablets 1:55:21 Taking Kanna at the Club 1:57:27 Conclusion