PHARM | 1st Gen Antipsychotics Haloperidol

STAT Stitch Deep Dive Podcast Beyond The Bedside di Regular Guy

S03
41:20
Note sull'episodio

💊 PHARM STUDY GUIDE: HALOPERIDOL (Haldol) Class: First-generation antipsychotic

🧠 MOA (80/20): High-potency D2 receptor antagonist → ↓ mesolimbic dopamine (helps positive symptoms). D2 block in other tracts drives side effects.

🧭 Dopamine Pathways (clinical relevance):

  • Mesolimbic: D2 block → ↓ hallucinations/delusions ✅.
  • Nigrostriatal: D2 block → EPS/pseudoparkinsonism ⚠️.
  • Tuberoinfundibular: D2 block → ↑ prolactin (galactorrhea, menstrual changes).

📋 Indications (common): Schizophrenia; acute agitation (IM lactate); Tourette’s tics; long-term adherence with decanoate IM depot (not IV). Some off- ... 

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