PHARM | TCAs Amitriptyline

STAT Stitch Deep Dive Podcast Beyond The Bedside di Regular Guy

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💊 PHARM STUDY GUIDE: AMITRIPTYLINE (Elavil) Class: Tricyclic Antidepressant (TCA)

🧠 MOA (80/20): Blocks neuronal reuptake of serotonin & norepinephrine; also anticholinergic, antihistamine, and sodium-channel effects → efficacy + side-effect burden. NCBI

📋 Indications (what you’ll actually see):

  • Major depressive disorder
  • Off-label, low dose: neuropathic pain, migraine preve ... 
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