A mechanism for hypoxia-induced inflammatory cell death in cancer

DOI: 10.1038/s41586-024-08136-y

Central Idea: This paper elucidates a novel mechanism for hypoxia-induced inflammatory cell death in cancer, specifically pyroptosis, mediated by a PTP1B-RNF213-CYLD-SPATA2 pathway. This pathway presents potential therapeutic targets for resistant hypoxic tumors.

Key Concepts:

• Hypoxia and Cancer: Hypoxia within the tumor microenvironment promotes resistance to therapy and cancer recurrence. This paper focuses on the mechanisms of cell death in hypoxic cancer cells.
• PTP1B and RNF213 Regulation: Protein tyrosine phosphatase PTP1B and the E3 ubiquitin ligase RNF213 are key players. PTP1B  ...