Note sull'episodio
Review: The Hallmarks of Cancer Immune Evasion
DOI: 10.1016/j.ccell.2024.09.010
Claudia Galassi, Timothy A. Chan, Ilio Vitale & Lorenzo Galluzzi
Central Idea: This review proposes a "Three Cs" framework (Camouflage, Coercion, and Cytoprotection) to categorize the diverse mechanisms cancer cells utilize to evade the immune system.
Key Concepts:
- Camouflage: Hiding from immune detection.
- Downregulation of MHC class I molecules and/or associated proteins (e.g., B2M, TAP1/2).
- Epigenetic silencing of MHC and antigen processing genes.
- Impaired chemoattraction through altered ATP, ANXA1, and ...