Medical Rewrites is the podcast that rewrites movie scenes with evidence-based medicine. Come for the clinical pearls, stay for the tangents.
This podcast analyzes movie scenes with medical plot points that fall short of best practices then rewrite the scene or dialogue.
Schedule: Q14 days on Wednesday
Guest experts: PRN
The rewrite today is for The Menu. The deep dive is about infections associated with eating dry aged meat. Movie suggestion form: https://tinyurl.com/8pa8svey References used in this episode Symposium review: An abundance of replacement heifers: What is the economic impact of raising more than are needed? https://pubmed.ncbi.nlm.nih.gov/32037180/ Eating and cooking retired dairy cow: https://livefrankly.co.uk/sustainable-food/what-is-retired-dairy-beef-how-to-cook-the-chefs-secret-weapon-at-home/ Investigating Bacterial Penetration of the Blood-Brain Barrier for the Pathogenesis, Prevention, and Therapy of Bacterial Meningitis. https://pubmed.ncbi.nlm.nih.gov/31805229/ Post-splenectomy Sepsis: A Review of the Literature. https://pubmed.ncbi.nlm.nih.gov/32195065/ Acute bacterial meningitis in adults. https://pubmed.ncbi.nlm.nih.gov/27265346/ Exploring the microbiological quality and safety of dry-aged beef: A cross-sectional study of loin surfaces during ripening and dry-aged beef steaks from commercial meat companies in Belgium. https://pubmed.ncbi.nlm.nih.gov/34809945/ Dry-aged beef manufactured in Japan: Microbiota identification and their effects on product characteristics. https://pubmed.ncbi.nlm.nih.gov/33648250/ Metabolic and microbial analyses of the surface and inner part of wet-aged and dry-aged beef. https://pubmed.ncbi.nlm.nih.gov/37807472/ Microbiota associated with commercial dry-aged beef in France. https://pubmed.ncbi.nlm.nih.gov/38448091/ National Outbreak Reporting System (NORS) https://wwwn.cdc.gov/norsdashboard/
The rewrite today is for We’re the Millers. The deep dive is about management of tarantula attack. Movie suggestion form: https://tinyurl.com/8pa8svey References used in this episode Tarantula bite references A verified spider bite and a review of the literature confirm Indian ornamental tree spiders (Poecilotheria species) as underestimated theraphosids of medical importance. Toxicon. https://pubmed.ncbi.nlm.nih.gov/24215987/ Wessel's tiger ornamental tarantula bite envenomation: A case report and venom analysis. https://pubmed.ncbi.nlm.nih.gov/36592763/ A Case Report on Generalised Muscle Spasms After Ornamental Tarantula Bites That Responded Well to Intravenous Calcium Gluconate Treatment. Cureus. https://pubmed.ncbi.nlm.nih.gov/37692640/ Tarantulas: eight-legged pharmacists and combinatorial chemists. https://pubmed.ncbi.nlm.nih.gov/15066413/ Animal Venom Peptides as a Treasure Trove for New Therapeutics Against Neurodegenerative Disorders. https://pubmed.ncbi.nlm.nih.gov/30378475/ Urticaria caused by tarantula hairs. https://pubmed.ncbi.nlm.nih.gov/4684884/ The optical imaging of tarantula hair corneal injury: One case report and review of the literature. https://pubmed.ncbi.nlm.nih.gov/28736046/ “Spider bite” infections "Spider bite" lesions are usually diagnosed as skin and soft-tissue infections. https://pubmed.ncbi.nlm.nih.gov/19939602/ A clone of methicillin-resistant Staphylococcus aureus among professional football players. https://pubmed.ncbi.nlm.nih.gov/15689585/ Treatment of spider venom-associated muscle cramps Muscle spasms - A common symptom following theraphosid spider bites? https://pubmed.ncbi.nlm.nih.gov/33493497/ Differential block of sodium and calcium channels by chlorpromazine in mouse neuroblastoma cells. https://pubmed.ncbi.nlm.nih.gov/2157837/ Chlorpromazine (thorazine) in the treatment of intractable hiccups. https://pubmed.ncbi.nlm.nih.gov/13221413/ Chlorpromazine in the treatment of stubborn hiccup. https://pubmed.ncbi.nlm.nih.gov/14374117/ Pharmacologic Interventions for Intractable and Persistent Hiccups: A Systematic Review. https://pubmed.ncbi.nlm.nih.gov/29079070/
Welcome back to Medical Rewrites. Let’s call this Season 2. That makes the unplanned sabbatical from last year feel purposeful. At the time of launching the podcast last Summer, I had written several episodes and had what I thought was a lot of runway. I was able to continue to write during the Fall semester. But when Spring semester hit, I was in the weeds. The other parts of my job like teaching and patient care are my priorities and they get the best version of myself. The podcast got the left overs. The writing felt burdensome and the creativity was inadequate. So I sacrificed the podcast until I was ready to write again. Which was this summer. I went to my Grandparents cabin, sat on the porch – which is the best spot to be able to steal wifi from the neighbors – I started writing again and made a plan for the year. This is the plan: episodes will be released every 4 weeks. There are bonus episodes as well but those dates have not been finalized. Thank you for your patience. Thank you for keeping Medical Rewrites in your podcast rotation. I hope you find lots of clinical pearls because I have been shucking a lot of oysters.
The rewrite today is for Trainwreck. The deep dive is about drug-drug interactions between alcohol and antibiotics. Movie suggestion form: https://tinyurl.com/8pa8svey References used in this episode Fact versus Fiction: a Review of the Evidence behind Alcohol and Antibiotic Interactions https://pubmed.ncbi.nlm.nih.gov/31871085/ Doxycycline PK after whiskey or wine https://pubmed.ncbi.nlm.nih.gov/7113712/ Doxycycline + rifampin for Brucellosis infection in rats fed alcohol https://pubmed.ncbi.nlm.nih.gov/16323439/ Doxycycline + rifampin PK changes in human Brucellosis infections https://www.ncbi.nlm.nih.gov/pmc/articles/PMC188288/ Long-term alcohol consumption and half-life of erythromycin and doxycycline https://pubmed.ncbi.nlm.nih.gov/1002368/ Tyramine concentrations in alcohol https://pubmed.ncbi.nlm.nih.gov/28824206/, https://pubmed.ncbi.nlm.nih.gov/34655830/ Linezolid and tyramine and increase in SBP https://pubmed.ncbi.nlm.nih.gov/11361052/ Cephalosporin induced disulfiram-like reaction: a retrospective review of 78 cases. https://pubmed.ncbi.nlm.nih.gov/24670024/ Cephalosporin induced hypoprothrombinemia due to side chains of N-methylthiotetrazole (latamoxef, cefmenoxime, cefoperazone, cefotetan, cefamandole) https://pubmed.ncbi.nlm.nih.gov/3350995/ Metronidazole plus alcohol in rats https://pubmed.ncbi.nlm.nih.gov/10798595/ RCT metronidazole plus alcohol in humans https://pubmed.ncbi.nlm.nih.gov/12022894/ Retro case-control of pts admitted after ethanol who received metronidazole https://pubmed.ncbi.nlm.nih.gov/37494646/ Z-drugs adverse reactions https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8077048/ Zolpidem plus alcohol and ICU admission https://pubmed.ncbi.nlm.nih.gov/20458214/
The rewrite today is for Knives Out. The deep dive is about pain management of musculoskeletal injuries. Movie suggestion form: https://tinyurl.com/8pa8svey References used in this episode Clinical Practice Guidelines for Pain Management in Acute Musculoskeletal Injury by the Orthopaedic Trauma Association Musculoskeletal Pain Task Force https://pubmed.ncbi.nlm.nih.gov/30681429/ Nonpharmacologic and Pharmacologic Management of Acute Pain From Non-Low Back, Musculoskeletal Injuries in Adults: A Clinical Guideline From the American College of Physicians and American Academy of Family Physicians INFOGRAPHIC INCLUDED https://pubmed.ncbi.nlm.nih.gov/32805126/ Oxycodone vs ibuprofen vs. combo tx for the treatment of pain after abdominal or pelvic surgery in women RCT https://pubmed.ncbi.nlm.nih.gov/15763605/ RCT topical diclofenac/menthol vs. placebo for ankle sprain pain https://pubmed.ncbi.nlm.nih.gov/28345425/ RCT topical diclofenac gel, ibuprofen gel, and ibuprofen gel with levomenthol for musculoskeletal injuries https://pubmed.ncbi.nlm.nih.gov/31353997/ RCT: ketorolac 60 mg IM vs ibuprofen 800 mg PO for acute musculoskeletal pain https://pubmed.ncbi.nlm.nih.gov/7618770/ RCT: ketorolac 60 mg vs 15 mg for acute musculoskeletal pain https://pubmed.ncbi.nlm.nih.gov/34365063/ Post-market surveillance study of ketorolac and GI bleeds https://pubmed.ncbi.nlm.nih.gov/8569017/ Nested-case control for NSAID-associated heart failure admissions https://pubmed.ncbi.nlm.nih.gov/27682515/ Drug Information summary about ketorolac duration by Christie Denton, PharmD, BCPS https://dig.pharmacy.uic.edu/faqs/2022-2/september-2022-faqs/what-evidence-is-there-for-the-5-day-maximum-with-the-use-of-ketorolac/