From a once-monthly GLP-1/GIP driving 16% weight loss to a twice-yearly HIV PrEP injection, this episode unpacks the most practice-changing updates in internal medicine. We cover new evidence in obesity care, MASH reversal, stroke anticoagulation timing, sarcoidosis management, COPD biologics, and the cardioprotective power of oral semaglutide. Plus, hear what every rising PGY-2 should know heading into senior year.