This episode bridges chemistry and quality by explaining how ibogaine is separated from plant material and purified to an API specification. Acid-base alkaloid partitioning and the distinction between crude total-alkaloid extract and purified ibogaine HCl form the conceptual foundation. Analytical identity and purity — via HPLC/UPLC, LC-MS, and NMR — are covered as orthogonal controls. Impurity profiling is addressed in detail: plant-related congeners, noribogaine, and process-related impurities. The episode emphasizes GMP specification thinking (assay, related substances, residual solvents, heavy metals) and the real-world harm driven by uncharacterized underground material.