Episode 4 follows raw material from field to feedstock, examining the agronomy of both source species and why cultivating iboga is genuinely difficult. The discussion covers wild collection versus cultivation in West Africa, the ethics of heritage and benefit-sharing under the Nagoya Protocol, and conservation pressures from overharvest. From a supply-security perspective appropriate to a future approved drug, the hosts address what a CDMO must grapple with. The episode concludes with emerging non-agricultural routes — plant cell culture and synthetic-biology production of iboga alkaloids — offering a forward-looking path to de-risking supply.