Neuroscience Perspectives

Neuroscience Perspectives

di Del Monte Institute for Neuroscience at the University of Rochester
Scienza

The Future of Memory: Single Neurons, Consciousness & Cognitive Decline

Join this conversation with the world-renowned neurosurgeon and neuroscientist, Dr. Itzhak Fried. In this episode of Neuroscience Perspectives, Dr. Fried, professor of neurosurgery, psychiatry, and biobehavioral sciences, and co-director of the UCLA Seizure Disorder Center at the UCLA School of Medicine he is a pioneering researcher and recipient of major international awards, including the Ramon y Cajal and Tsubokawa Awards—joins us to explore the neural basis of memory, will, and human behavior. From developing methods to record single neurons in the human brain to investigating how we might prevent “cognitive catastrophe” through minimally invasive memory prosthetics, Dr. Fried’s work is reshaping our understanding of consciousness itself. He discusses breakthroughs born from epilepsy surgery, the famous “Jennifer Aniston neuron,” and what his international clinical and research career has taught him about the future of neuroscience. #Neuroscience #BrainResearch #EpilepsySurgery #Science #memory #memory #CognitiveNeuroscience #NeuralRecording #ConsciousnessStudy #BrainHealth #sciencepodcast #podcast 🧠 Stay Connected Subscribe: https://www.youtube.com/@URNeuroscience X: https://x.com/URNeuroscience BlueSky: https://bsky.app/profile/urneuroscience.bsky.social LinkedIn: https://www.linkedin.com/company/urneuroscience/ 🧠Experts in this Episode: Itzhak Fried, MD, PhD: https://www.uclahealth.org/providers/itzhak-fried John Foxe, PhD: https://www.urmc.rochester.edu/people/112360965-john-j-foxe 🧠Labs Mentioned: Cognitive Neurophysiology Laboratory: https://friedcnl.ucla.edu/team/ Frederick J. and Marion A. Schindler Cognitive Neurophysiology Lab: https://urmc.info/1RG
E36
20 nov 2025
39:24

What Happens When Science Meets Storytelling? With Best-Selling Author & Neuroscientist Lisa Genova

In this episode of Neuroscience Perspectives, host John Foxe, PhD, sits down with neuroscientist and New York Times bestselling author Dr. Lisa Genova — acclaimed for her groundbreaking novel Still Alice and her powerful storytelling that brings neurological diseases to life. Dr. Genova bridges science and storytelling to deepen public understanding of conditions such as Alzheimer’s, Huntington’s, ALS, autism, and bipolar disorder, inspiring empathy for those affected and reshaping how these diseases are perceived beyond the lab and clinic. Watch to explore how narrative can be a powerful tool for translating neuroscience, fostering compassion, and influencing the dialogue around brain health. #Neuroscience #BrainHealth #LisaGenova Stay Connected Subscribe: https://www.youtube.com/@URNeuroscience X: https://x.com/URNeuroscience BlueSky: https://bsky.app/profile/urneuroscience.bsky.social LinkedIn: https://www.linkedin.com/company/urneuroscience/ Experts in this Episode: Lisa Genova, PhD: https://www.lisagenova.com/ John Foxe, PhD: https://www.urmc.rochester.edu/people/112360965-john-j-foxe
E35
17 ott 2025
39:51

Can the Brain Be Repaired by Replacing Its Cells?

In this episode of Neuroscience Perspectives, Steven Goldman, MD, PhD, URMC Distinguished Professor in Neurosciences at the University of Rochester Medical Center, discusses groundbreaking neuroscience research on brain cell repair, stem cell therapy, and regenerative medicine. Learn how his early research in birds has led to research that shows the adult brain can generate new neurons that integrate into key motor circuits. These findings demonstrate that stimulating natural brain processes may help repair damaged neural networks in Huntington's and other diseases. Dr. Goldman described decades of research in glial cells that are shaping our understanding of brain health and allowing the exploration of new approaches to treating Huntington’s disease, multiple sclerosis, and Alzheimer’s disease. #Neuroscience #BrainHealth #StemCells #Alzheimers #MultipleSclerosis #RegenerativeMedicine #Neurodegeneration #Podcast
E34
25 set 2025
43:19

RE-RELEASE: Jessica Cardin, PhD - From Daydreaming To Laser Focus How Your Brain Changes

In this episode of Neuroscience Perspectives, take on the complex circuits of the brain with Jessica Cardin, PhD, professor of neuroscience at Yale University School of Medicine. Join host John Foxe, PhD, director of the Del Monte Institute for Neuroscience at the University of Rochester, as he and Dr. Cardin discuss how brain states shift—from zoning out to laser focus—and the chemical signals and non-neuronal cells that help drive those changes. Discover how her lab is harnessing new technologies and big data approaches, including machine learning, to unravel how the brain integrates countless signals to guide decision-making and behavior. From exploring autism- and schizophrenia-related genes to studying models of aging and Alzheimer’s disease, Cardin’s research highlights both the promise and the challenges of understanding such a complex system. Subscribe to Neuroscience Perspectives today! #podcast #neuroscience #science #research #brain Stay Connected Subscribe: https://www.youtube.com/@URNeuroscience X: https://x.com/URNeuroscience BlueSky: https://bsky.app/profile/urneuroscience.bsky.social LinkedIn: https://www.linkedin.com/company/urneuroscience/ Experts in this Episode: Jessica Cardin, PhD: https://medicine.yale.edu/profile/jess-cardin/ John Foxe, PhD: https://www.urmc.rochester.edu/people/112360965-john-j-foxe Labs Mentioned: Cardin Lab: https://cardinlab.org Frederick J. and Marion A. Schindler Cognitive Neurophysiology Lab: https://urmc.info/1RG
E33
21 ago 2025
24:19

Can the Brain Help Predict Chronic Pain Risk

In this episode of Neuroscience Perspectives, we explore one of medicine’s most complex and pervasive challenges—chronic pain. Host John Foxe, PhD, director of the Del Monte Institute for Neuroscience at the University of Rochester, sits down with Paul Geha, MD, associate professor of Psychiatry, Neuroscience, Neurology, and Dentistry at the University of Rochester Medical Center. Together, they unpack the ways our brains perceive pain and the impact it can have on well-being.Dr. Geha shares his research into how brain connectivity and structure change in patients with chronic pain—and how these changes might help us predict who is at risk for conditions like low back pain or failed surgery outcomes. They discuss the psychological dimensions of pain, the challenges of diagnosis and treatment, and how research is charting a new course to change traditional injury-based models of pain.Could brain biomarkers reveal who is most vulnerable to chronic pain? Might psychedelics offer a new avenue for relief? And how can science better serve the millions suffering from pain that cannot be quantified in an exam or on a scan? ☝️ Be sure to follow and like: Neuroscience Perspectives! 🧠 Stay Connected Subscribe: https://www.youtube.com/@URNeuroscienceX: https://x.com/URNeuroscienceBlueSky: https://bsky.app/profile/urneuroscience.bsky.socialLinkedIn: https://www.linkedin.com/company/urneuroscience 🧠 Experts in this Episode: Paul Geha, MD: https://www.urmc.rochester.edu/people/112361971-paul-geha John Foxe, PhD: https://www.urmc.rochester.edu/people/112360965-john-j-foxe🧠 Labs Mentioned: Geha Lab: https://www.urmc.rochester.edu/labs/geha Frederick J. and Marion A. Schindler Cognitive Neurophysiology Lab: https://urmc.info/1RG
E32
24 lug 2025
38:03

The Brain vs AI: Dr. Doris Tsao & Why the Brain is More Efficient than AI

Join Dr. John Foxe, Director of the Del Monte Institute for Neuroscience at the University of Rochester, as he welcomes renowned neuroscientist Dr. Doris Tsao to Neuroscience Perspectives. Dr. Tsao shares how her pioneering research has transformed our understanding of how the brain processes visual information. Her lab helped discover that it only takes a few hundred neurons to encode any face – for reference, there are more than a few billion neurons in the brain. This conversation explores the intersection of neuroscience, math, and AI. We also discuss her academic journey—from Caltech to Harvard, and her current role at UC Berkeley. She also shares how having the right mentor was pivotal to her scientific training. Dr. Tsao shares the importance of science communication and what it means to pursue truth in a world shaped by both neural networks and human curiosity. 🧠Stay Connected Subscribe: / @urneuroscience X: https://x.com/URNeuroscience BlueSky: https://bsky.app/profile/urneuroscience LinkedIn: https://www.linkedin.com/company/urneuroscience 🧠Experts in this Episode: Doris Tsao, PhD: https://vcresearch.berkeley.edu/faculty/doris-tsao John Foxe, PhD: https://www.urmc.rochester.edu/people/112360965-john-j-foxe 🧠Labs Mentioned: Tsao Lab: https://tsaolab.berkeley.edu/ Frederick J. and Marion A. Schindler Cognitive Neurophysiology Lab: https://urmc.info/1RG
E31
18 giu 2025
23:16

RE-RELEASE: Kia Nobre, PhD - How Is the Brain Organized for Adaptive Thinking and Behavior?

Kia Nobre, PhD, is the director of the Center for Neurocognition and Behavior at the Wu Tsai Institute at Yale University. Her discoveries have revolutionized our scientific understanding of the human mind and brain. This episode was originally released on 6/20/2024. She tells John Foxe, PhD, director of the Del Monte Institute for Neuroscience, about the great gift she acquired as a child that leveraged her education at an early age. Nobre recently returned to her alma mater after spending the majority of her career at Oxford University where she held several leadership roles, including the director of the Oxford Centre for Human Brain Activity. #podcast #brain #neuroscience #humanbrain #humanbehavior #understanding #yaleuniversity #oxford 🧠Stay Connected Subscribe: https://www.youtube.com/@URNeuroscience X: https://x.com/URNeuroscience BlueSky: https://bsky.app/profile/urneuroscience.bsky.social LinkedIn: https://www.linkedin.com/company/urneuroscience/ 🧠Experts in this Episode: Kia Nobre, PhD: https://psychology.yale.edu/people/kia-nobre John Foxe, PhD: https://www.urmc.rochester.edu/people/112360965-john-j-foxe 🧠Labs Mentioned: Frederick J. and Marion A. Schindler Cognitive Neurophysiology Lab: https://urmc.info/1RG Brain & Cognition Laboratory: https://www.brainandcognition.org/
E30
22 mag 2025
42:51

Exploring the Impact of Environmental Chemicals on Brain Health

Dr. Deborah Cory-Slechta is a leading researcher at the University of Rochester. She is a professor with appointments in Environmental Medicine, Neuroscience, and Public Health Sciences. She co-leads the University’s Intellectual and Developmental Disabilities Research Center Animal Behavior and Neurophysiology Core. She has chaired the Department of Environmental Medicine and led its National Institute of Environmental Health Sciences Core Center Grant. Her research explores the effects of environmental chemicals—such as air pollution, metals, and pesticides—on brain health. With decades of expertise, Dr. Cory-Slechta discusses the impact that exposures to chemicals in our environment have on neurodegenerative and neurodevelopmental disorders. Learn about the crucial intersection of neuroscience, toxicology, and public health. And how the passion to give back drives Dr. Cory-Slechta. #neuroscience #environmentalhealth #toxicology #podcast 🧠Stay Connected Subscribe: https://www.youtube.com/@URNeuroscience X: https://x.com/URNeuroscience BlueSky: https://bsky.app/profile/urneuroscience.bsky.social LinkedIn: https://www.linkedin.com/company/urneuroscience/ 🧠Experts in this Episode: John Foxe, PhD: https://www.urmc.rochester.edu/people/112360965-john-j-foxe Deborah Cory-Slechta, PhD: https://www.urmc.rochester.edu/people/112358303-deborah-a-slechta 🧠Labs & Institutes Mentioned: Frederick J. and Marion A. Schindler Cognitive Neurophysiology Lab: https://urmc.info/1RG Cory-Slechta Lab: https://www.urmc.rochester.edu/labs/cory-slechta Institute for Human Health and the Environment: https://www.urmc.rochester.edu/institute-for-human-health-and-the-environment Environmental Health Sciences Center: https://www.urmc.rochester.edu/environmental-health-sciences
E29
25 apr 2025
42:01

Neuroscience & RNA Biology: How mRNA Decay Shapes Health & Disease

How does RNA biology influence cell function, gene expression, and disease mechanisms? In this episode of Neuroscience Perspectives, host John Foxe, PhD, director of the Del Monte Institute for Neuroscience at the University of Rochester (UR), sits down with Lynne Maquat, PhD, director of the Center for RNA Biology at UR, and J. Lowell Orbison Endowed Chair and Professor of Biochemistry & Biophysics, to explore groundbreaking research in mRNA decay, cellular quality control, and translational research. Dr. Maquat, a world-renowned scientist, shares insights into how fundamental biochemistry, molecular biology, and biophysics drive scientific discovery—from understanding cystic fibrosis, fragile X syndrome, and intellectual disabilities to advancing cancer research, autism studies, and stem cell research. They also discuss the impact of mRNA vaccines, vaccine development, and COVID-19 on modern medicine. Beyond the lab, they dive into the importance of scientific integrity, mentoring scientists, research collaboration, and science education. 🔬 Discover how basic and applied research pave the way for personalized treatments, neurobiology breakthroughs, and scientific innovation. #Neuroscience #RNABiology #ScientificDiscovery #mRNADecay #GeneExpression #TranslationalResearch #CancerResearch #VaccineDevelopment #AutismResearch #StemCellResearch #ScienceEducation #ScienceCommunication 🧠 Stay Connected Subscribe: https://www.youtube.com/@URNeuroscience X: https://x.com/URNeuroscience BlueSky: https://bsky.app/profile/urneuroscience.bsky.social LinkedIn: https://www.linkedin.com/company/urneuroscience/ 🧠 Experts in this Episode: Lynne Maquat, PhD: https://www.urmc.rochester.edu/people/112359023-lynne-e-maquat John Foxe, PhD: https://www.urmc.rochester.edu/people/112360965-john-j-foxe 🧠 Labs Mentioned: Maquat Lab: https://www.urmc.rochester.edu/labs/maquat Frederick J. and Marion A. Schindler Cognitive Neurophysiology Lab: https://urmc.info/1RG
E28
27 mar 2025
33:55

Your Brain & Perception: Using Science to Understand How We See the World

How brain dynamics, perception, and neural processing offer a deeper understanding of how brain activity shapes our understanding of the world. Christopher Moore, PhD, associate director of the Carnegie Institute of Brain Science and professor of Neuroscience at Brown University, joins Neuroscience Perspectives host John Foxe, PhD, director of the Del Monte Institute for Neuroscience at the University of Rochester, in a fascinating discussion that includes why the term neuroscience may be outdated. Dive into Moore’s research that studies neocortical dynamics – changes in brain activity at the millisecond to the second timescale—and how his lab aims to understand the mechanisms at play and what these changes mean for perception. He and Dr. Foxe also share how they met during a pivotal moment in their careers, which was also a profound moment in neuroscience research. #neuroscience #brainscience #perception #podcast 🧠Stay Connected Subscribe: https://www.youtube.com/@URNeuroscience X: https://x.com/URNeuroscience BlueSky: https://bsky.app/profile/urneuroscience.bsky.social LinkedIn: https://www.linkedin.com/company/urneuroscience/ 🧠Experts in this Episode: Christopher Moore, PhD: https://vivo.brown.edu/display/cm78 John Foxe, PhD: https://www.urmc.rochester.edu/people/112360965-john-j-foxe 🧠Labs Mentioned: The Moore Lab: https://www.themoorelab.org/ Frederick J. and Marion A. Schindler Cognitive Neurophysiology Lab: https://urmc.info/1RG
E27
27 feb 2025
35:26
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