Episode 11 Dr. Joan Clària “SPMs in Liver Disease & Obesity: Resolution Biology from Adipose Tissue to Cirrhosis"
the SPM podcast by Herbert Aberson
Episode notes
Episode 11 Dr. Joan Clària
In this episode we welcome Professor Dr. Joan Clària, a leading voice in inflammation resolution biology and one of the pioneers exploring how the body actively resolves inflammation through lipid mediators.
We discuss his career path from clinical biochemistry at Hospital Clínic Barcelona to postdoctoral work with Charles Serhan, his foundational research on SPMs in liver disease and obesity, the role of resolution deficits in adipose tissue inflammation and metabolic-associated fatty liver disease (MAFLD/MASH), and the translational potential of SPMs, omega-3 precursors, and stable analogs.
Key themes include the unique clinical-biochemical perspective he brings to SPM biology, the importance of on-site SPM production in tissues, challenges in reversing established fibrosis, the need for more res ...