From poker to prescription skinca...

From poker to prescription skincare – building a £160m business with James Mishreki

Smart Beauty by Viola Levy
S4 · E5
Jan 23, 2026
30:14

Episode notes

James Mishreki went from professional poker player to building Skin+Me, a personalised prescription skincare company now valued at £160 million. But what really drives someone to keep playing when the stakes get this high?

In this episode, James talks about how poker taught him to detach from outcomes and make decisions with incomplete information. We get into the weekend Silicon Valley Bank collapsed and he thought he'd lost everything — £13 million gone overnight — and the 20-30 minutes where he felt "completely lost" before the founder community rallied.

He explains why he believes resilience can't be taught, and why if you have to convince yourself to start a company, you probably shouldn't. He describes going on BBC News "looking like a ghost" after two days without sleep, and why he now calls himself "addicted to company building," comparing entrepreneurship to a dopamine hit he can't quit.

skinandme.com

Keywords

skincare
beauty
copywriting
branding
business
health
wellness
founder
entrepreneurship