IBM Z mainframes remain the cornerstone of enterprise IT, processing the majority of global business transactions. Their unparalleled reliability, scalability, and security make them indispensable for critical business operations. However, as hybrid IT environments become more widespread, Chief Information Security Officers (CISOs) face growing challenges in securing mainframe data while ensuring smooth integration with modern platforms. This podcast explores the latest trends in mainframe security, addresses the challenges of data governance, and presents practical strategies to protect and leverage mainframe data in an increasingly complex threat landscape.