In this enlightening episode, we sit down with Dr. Longo to explore the intriguing role of fasting-mimicking diet (FMD) cycles in reducing Alzheimer's Disease (AD) symptoms and cognitive decline. The FMD cycles have demonstrated considerable potential in decreasing various aging and disease risk factors. As discussed by Dr. Longo, recent studies reveal that these diet cycles can reduce cognitive decline and AD pathology in mouse models more effectively than protein restriction cycles. Furthermore, long-term FMD cycles have demonstrated significant potential in reducing hippocampal Aβ load and hyperphosphorylated tau, enhancing neural stem cell genesis, decreasing the number of microglia, and reducing the expression of neuroinflammatory genes, including NADPH oxidase (Nox2). The deletion of Nox2 in mice or treatment with an NADPH oxidase inhibitor ...