In this enlightening episode, we engage in a deep exploration of the role of long noncoding RNAs (lncRNAs) in learning processes, focusing particularly on fear-related learning, with Dr. Bredy. His breakthrough research has uncovered a substantial population of lncRNAs that respond in adult mice's infralimbic prefrontal cortex to fear-related learning.

Dr. Bredy and his team used an advanced technique called RNA Capture-seq to identify these lncRNAs, supplementing these findings with cell-type-specific ATAC-seq applied to neurons selectively activated by fear extinction learning. Through this approach, they discovered 434 inducible lncRNAs that originate from enhancer regions near protein-coding genes.

Among these lncRNAs, the team found an experience-induced lncRNA they named ADRAM (activity-dependent lncRNA associated with memory).  ...