Episode notes
Today, we delve into a groundbreaking frontier in bio-imaging with Dr. MacKenzie, who is pioneering methods to observe and understand the world of chiral molecular interactions – an area that, up to now, was challenging to visualize.
The Significance of Chirality:
Life's molecular machinery relies on chiral building blocks, yet monitoring these in live cells remained elusive.
Luminescent chiral molecules provide a unique optical signature, shedding light on the environment, shape, and binding state.
Introducing the CPL Laser Scanning Confocal Microscope (CPL-LSCM):
This revolutionary device can capture chiroptical contrast in live-cell imaging of both natural and designed CPL-active cellular probes.
Achievements also include the success of using two-photon excitation, fully restoring the CPL spectrum in the pro ...