Shining New Light on Chiral Molecules: Innovations in CPL Bio-Imaging with Dr. MacKenzie

Science Society by Catarina Cunha

Episode notes

Today, we delve into a groundbreaking frontier in bio-imaging with Dr. MacKenzie, who is pioneering methods to observe and understand the world of chiral molecular interactions – an area that, up to now, was challenging to visualize.

The Significance of Chirality:

Life's molecular machinery relies on chiral building blocks, yet monitoring these in live cells remained elusive.

Luminescent chiral molecules provide a unique optical signature, shedding light on the environment, shape, and binding state.

Introducing the CPL Laser Scanning Confocal Microscope (CPL-LSCM):

This revolutionary device can capture chiroptical contrast in live-cell imaging of both natural and designed CPL-active cellular probes.

Achievements also include the success of using two-photon excitation, fully restoring the CPL spectrum in the pro ... 

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Keywords
2pe cpl spectroscopydiffraction limited enantioselective chiral contrast imagingchiralitymolecular machinerytwo photon excitationemissive chiral probesdistinct enantiomerschiral europium complexbioimagingchiral building blocks