Episode notes
Human tissues are invaluable resources for pharmaceutical research. They provide information about disease pathophysiology - and equally importantly, healthy function; confirmation (or refutation) of potential drug targets; validation (or otherwise) of other models employed; and functional models for assessing drugs’ effects, whether beneficial or undesirable, in the most appropriate environment that can be replicated outside the human body. While human tissues have long been prized by pathologists in furthering our under- standing of disease processes, there is a growing appreciation of their value at the late pre-clinical stage of drug discovery. Human tissues’ potential to contribute to earlier phases of the process, before significant resources have been expended, is also now gaining recognition ... ... Read moreKeywords
researchpathophysiologydrug discoveryhuman tissuesbiosamples