In this episode, we delve deep into groundbreaking research that explores the profound relationship between psychedelics, neuroplasticity, and the BDNF-TrkB pathway. We unpack the potential of psychedelics as powerful modulators of brain function, their implications for depression treatment, and the challenges that lie ahead. Join us as we navigate the intricate dance of molecules, shedding light on the therapeutic promise of these once-controversial compounds.
Paper: Moliner, R., Girych, M., Brunello, C.A. et al. Psychedelics promote plasticity by directly binding to BDNF receptor TrkB. Nat Neurosci 26, 1032–1041 (2023). https://doi.org/10.1038/s41593-023-01316-5