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Dr Charles N. Serhan part 2 "the Father of Resolution Physiology"
Dr Charles N. Serhan part 1 "the Father of Resolution Physiology"
di Herbert Aberson
Dr. Charles N. Serhan part 1 Unlocking the Resolution of Inflammation: Pioneering Insights with the Father of Resolution Physiology Welcome to the SPM podcast, the podcast about Specialized Pro-Resolving Mediators. Subscribe, leave a comment, and share this episode with anyone passionate about cutting-edge science and better health outcomes. Episode Summary : In this enlightening episode, we are honored to welcome one of the most influential scientists in inflammation research and the world leader in resolution biology: Dr. Charles N. Serhan. Often called the “father of resolution physiology,” Dr. Serhan joins us to discuss his groundbreaking work on specialized pro-resolving mediators (SPMs), the natural pathways that actively resolve inflammation, and the exciting potential of resolution pharmacology for treating chronic diseases, reperfusion injury, and beyond. Dr. Serhan shares stories from his remarkable career, the discovery of novel lipid mediators like resolvins, protectins, and maresins, and how these molecules are transforming our understanding of inflammation—not as something to simply block, but to actively resolve and return tissues to homeostasis. Guest Bio • Dr. Charles N. Serhan is the Simon Gelman Professor of Anaesthesia in Biochemistry and Molecular Pharmacology at Harvard Medical School and Professor of Oral Medicine, Infection, and Immunity at Harvard School of Dental Medicine. He directs the Center for Experimental Therapeutics and Reperfusion Injury (CETRI) at Brigham and Women’s Hospital, where his team continues to push the boundaries of resolution pharmacology. •. He completed postdoctoral training at the Karolinska Institute in Stockholm under Nobel laureate Bengt Samuelsson. • Dr. Serhan joined the Harvard faculty in 1987, and in 1995 he established the CETRI lab. A prolific researcher with hundreds of publications, numerous patents, and international acclaim—including honorary degrees from Harvard, University College Dublin, and Queen Mary University of London • Dr. Serhan is known not only for his scientific achievements but for his generous recognition of the many talented scientists who have trained and collaborated in his lab, many of whom now lead their own independent research programs. Key Topics Covered : • The paradigm shift from anti-inflammation to pro-resolution biology. Discovery and therapeutic potential of resolvins, protectins, maresins, and other SPMs. Links between omega-3 fatty acids, diet, and resolution pathways Applications in chronic inflammatory diseases, reperfusion injury, pain management, and perioperative care. Future directions in resolution pharmacology Follow the CETRI / Serhan Lab Twitter/X:@CNSerhanLab Lab website: serhanlab.bwh.harvard.edu Seminal Review: Serhan, C.N. Pro-resolving lipid mediators are leads for resolution physiology. Nature (2014). This highly influential review outlines the discovery and mechanisms of specialized pro-resolving mediators (SPMs), including resolvins, protectins, and maresins, and establishes their central role in actively resolving inflammation and restoring tissue homeostasis. Recent Lecture: Watch Dr. Serhan’s presentation from the 2026 Oslo Inflammation Resolution Conference: “Pro-Resolving Chemical Mediators and Mechanisms in Resolution of Inflammation: Novel Resolvins for Resolution Medicine” https://www.mn.uio.no/farmasi/english/research/news-and-events/events/conferences/inflammation-resolution-2026/Recordings%20of%20scientific%20presentations/ .
Dr. Charles N. Serhan part 1 Unlocking the Resolution of Inflammation: Pioneering Insights with the Father of Resolution Physiology Welcome to the SPM podcast, the podcast about Specialized Pro-Resolving Mediators. Subscribe, leave a comment, and share this episode with anyone passionate about cutting-edge science and better health outcomes. Episode Summary : In this enlightening episode, we are honored to welcome one of the most influential scientists in inflammation research and the world leader in resolution biology: Dr. Charles N. Serhan. Often called the “father of resolution physiology,” Dr. Serhan joins us to discuss his groundbreaking work on specialized pro-resolving mediators (SPMs), the natural pathways that actively resolve inflammation, and the exciting potential of resolution pharmacology for treating chronic diseases, reperfusion injury, and beyond. Dr. Serhan shares stories from his remarkable career, the discovery of novel lipid mediators like resolvins, protectins, and maresins, and how these molecules are transforming our understanding of inflammation—not as something to simply block, but to actively resolve and return tissues to homeostasis. Guest Bio • Dr. Charles N. Serhan is the Simon Gelman Professor of Anaesthesia in Biochemistry and Molecular Pharmacology at Harvard Medical School and Professor of Oral Medicine, Infection, and Immunity at Harvard School of Dental Medicine. He directs the Center for Experimental Therapeutics and Reperfusion Injury (CETRI) at Brigham and Women’s Hospital, where his team continues to push the boundaries of resolution pharmacology. •. He completed postdoctoral training at the Karolinska Institute in Stockholm under Nobel laureate Bengt Samuelsson. • Dr. Serhan joined the Harvard faculty in 1987, and in 1995 he established the CETRI lab. A prolific researcher with hundreds of publications, numerous patents, and international acclaim—including honorary degrees from Harvard, University College Dublin, and Queen Mary University of London • Dr. Serhan is known not only for his scientific achievements but for his generous recognition of the many talented scientists who have trained and collaborated in his lab, many of whom now lead their own independent research programs. Key Topics Covered : • The paradigm shift from anti-inflammation to pro-resolution biology. Discovery and therapeutic potential of resolvins, protectins, maresins, and other SPMs. Links between omega-3 fatty acids, diet, and resolution pathways Applications in chronic inflammatory diseases, reperfusion injury, pain management, and perioperative care. Future directions in resolution pharmacology Follow the CETRI / Serhan Lab Twitter/X:@CNSerhanLab Lab website: serhanlab.bwh.harvard.edu Seminal Review: Serhan, C.N. Pro-resolving lipid mediators are leads for resolution physiology. Nature (2014). This highly influential review outlines the discovery and mechanisms of specialized pro-resolving mediators (SPMs), including resolvins, protectins, and maresins, and establishes their central role in actively resolving inflammation and restoring tissue homeostasis. Recent Lecture: Watch Dr. Serhan’s presentation from the 2026 Oslo Inflammation Resolution Conference: “Pro-Resolving Chemical Mediators and Mechanisms in Resolution of Inflammation: Novel Resolvins for Resolution Medicine” https://www.mn.uio.no/farmasi/english/research/news-and-events/events/conferences/inflammation-resolution-2026/Recordings%20of%20scientific%20presentations/ .
Episode 6 Dr. Valerio Chiurchiù "Resolution Biology Meets the Brain: SPMs in Neuroinflammation, Multiple Sclerosis & Neurodegenerative Diseases" Welcome to the SPM Podcast, the podcast about Specialized Pro-Resolving Mediators. Subscribe, leave a comment, and share this episode with anyone interested in brain health, neuroinflammation, and cutting-edge resolution science. Episode Summary: In this enlightening episode, we welcome Dr. Valerio Chiurchiù, a leading expert in the resolution of neuroinflammation and the role of Specialized Pro-Resolving Mediators (SPMs) in brain health. Guest Bio: Dr Valerio Chiurchiù, PhD, is the Head of the Laboratory of Neuroinflammation and Resolution at the Institute of Translational Pharmacology (CNR) and the European Center for Brain Research at IRCCS Santa Lucia Foundation in Rome, Italy. He is also an Adjunct Professor at Università Campus Bio-Medico di Roma. With over 18 years of research experience, Dr. Chiurchiù has pioneered work on the immunomodulatory functions of bioactive lipids, including endocannabinoids and Specialized Pro-Resolving Mediators (SPMs). His research focuses on how SPMs (such as resolvins, lipoxins, and maresins) regulate innate and adaptive immunity in the brain, with particular emphasis on neuroinflammatory and neurodegenerative diseases. Resources Mentioned: Video's: Oslo resolution conference presentations https://www.mn.uio.no/farmasi/english/research/news-and-events/events/conferences/inflammation-resolution-2026/Recordings%20of%20scientific%20presentations/ Key Papers: SPM's: Specialized Pro-resolving Lipid Mediators and Glial Cells: Emerging Candidates for Brain Homeostasis and Repair Frontiers in Cellular Neuroscience, 2021 https://www.frontiersin.org/journals/cellular-neuroscience/articles/10.3389/fncel.2021.673549/full Pro-resolving lipid mediator lipoxin A4 attenuates neuro-inflammation Cell Reports, 2021 https://www.sciencedirect.com/science/article/pii/S2211124721005507 Multiple Sclerosis: Specialized pro-resolving lipid mediators are differentially altered in peripheral blood of patients with multiple sclerosis and attenuate monocyte and blood-brain barrier dysfunction Haematologica, 2020 https://haematologica.org/article/view/9980 Parkinson disease: Blunting neuroinflammation with resolvin D1 prevents early pathology in a rat model of Parkinson’s disease Nature Communications, 2019 https://www.nature.com/articles/s41467-019-11928-w Alzheimer and Parkinson’s disease: Lipidomics of Bioactive Lipids in Alzheimer’s and Parkinson’s Diseases: Where Are We? International Journal of Molecular Sciences, 2022 https://www.mdpi.com/1422-0067/23/11/6235 IRCCS Santa Lucia Foundation – Dr. Valerio Chiurchiù Lab https://www.hsantalucia.it/cv/valerio-chiurchi%C3%B9