Paroxetine: Core Clinical Profile (80/20 Summary)

1. Fundamental Overview & Warnings Paroxetine is an oral selective serotonin reuptake inhibitor (SSRI). It carries a severe Boxed Warning for increasing the risk of suicidal thoughts and behaviors in children, adolescents, and young adults (under 24 years old). It is not FDA-approved for pediatric patients, and chronic use may cause pediatric growth inhibition by suppressing growth hormone secretion. The National Institute for Occupational Safety and Health (NIOSH) classifies it as a hazardous drug, requiring specialized protective equipment (e.g., gloves, protective gowns) during handling, manipulation, or administration. It must not be used during pregnancy due to the risk of teratogenesis.

2. Indications & Administration Par ...