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Medical Rewrites

Medical Rewrites

por Meghan Jeffres

Medicina Ciencias de la Vida

Temporada 2

Edward Scissorhands – prevention of skin infections

The rewrite today is for Edward Scissorhands. The deep dive is about prevention of infection from skin injuries. Movie suggestion form: https://tinyurl.com/8pa8svey References used in this episode Topical antibiotic sources Effectiveness of calamine lotion as an adjunctive therapy to mometasone furoate ointment in the treatment of infant eczema: A retrospective study. Medicine (Baltimore). 2022 Sep 2;101(35):e30237.. https://pubmed.ncbi.nlm.nih.gov/36107506/ The value of prophylactic antibiotics for simple lacerations. Surg Gynecol Obstet. 1983 Feb;156(2):212-6.. https://pubmed.ncbi.nlm.nih.gov/6337421/ The natural history of streptococcal skin infection: prevention with topical antibiotics. J Am Acad Dermatol. 1985 Aug;13(2 Pt 1):207-12. https://pubmed.ncbi.nlm.nih.gov/2995463/ Prospective evaluation of topical antibiotics for preventing infections in uncomplicated soft-tissue wounds repaired in the ED. Acad Emerg Med. 1995 Jan;2(1):4-10. https://pubmed.ncbi.nlm.nih.gov/7606610/ A prospective, randomized pilot evaluation of topical triple antibiotic versus mupirocin for the prevention of uncomplicated soft tissue wound infection. Am J Emerg Med. 2004 Jan;22(1):1-3. https://pubmed.ncbi.nlm.nih.gov/14724869/ Tetanus sources Tetanus. Lancet. 2019 Apr 20;393(10181):1657-1668. https://pubmed.ncbi.nlm.nih.gov/30935736/ ACIP recommendations on TdP vaccine 2019 https://pubmed.ncbi.nlm.nih.gov/31971933/ ACIP recommendations on Td prevention and vaccination in 2018 https://pubmed.ncbi.nlm.nih.gov/29702631/ Tetanus surveillance CDC https://www.cdc.gov/tetanus/php/surveillance/index.html

The Menu - Infection from dry aged beef

The rewrite today is for The Menu. The deep dive is about infections associated with eating dry aged meat. Movie suggestion form: https://tinyurl.com/8pa8svey References used in this episode Symposium review: An abundance of replacement heifers: What is the economic impact of raising more than are needed? https://pubmed.ncbi.nlm.nih.gov/32037180/ Eating and cooking retired dairy cow: https://livefrankly.co.uk/sustainable-food/what-is-retired-dairy-beef-how-to-cook-the-chefs-secret-weapon-at-home/ Investigating Bacterial Penetration of the Blood-Brain Barrier for the Pathogenesis, Prevention, and Therapy of Bacterial Meningitis. https://pubmed.ncbi.nlm.nih.gov/31805229/ Post-splenectomy Sepsis: A Review of the Literature. https://pubmed.ncbi.nlm.nih.gov/32195065/ Acute bacterial meningitis in adults. https://pubmed.ncbi.nlm.nih.gov/27265346/ Exploring the microbiological quality and safety of dry-aged beef: A cross-sectional study of loin surfaces during ripening and dry-aged beef steaks from commercial meat companies in Belgium. https://pubmed.ncbi.nlm.nih.gov/34809945/ Dry-aged beef manufactured in Japan: Microbiota identification and their effects on product characteristics. https://pubmed.ncbi.nlm.nih.gov/33648250/ Metabolic and microbial analyses of the surface and inner part of wet-aged and dry-aged beef. https://pubmed.ncbi.nlm.nih.gov/37807472/ Microbiota associated with commercial dry-aged beef in France. https://pubmed.ncbi.nlm.nih.gov/38448091/ National Outbreak Reporting System (NORS) https://wwwn.cdc.gov/norsdashboard/

We’re the Millers – spider bites

The rewrite today is for We’re the Millers. The deep dive is about management of tarantula attack. Movie suggestion form: https://tinyurl.com/8pa8svey References used in this episode Tarantula bite references A verified spider bite and a review of the literature confirm Indian ornamental tree spiders (Poecilotheria species) as underestimated theraphosids of medical importance. Toxicon. https://pubmed.ncbi.nlm.nih.gov/24215987/ Wessel's tiger ornamental tarantula bite envenomation: A case report and venom analysis. https://pubmed.ncbi.nlm.nih.gov/36592763/ A Case Report on Generalised Muscle Spasms After Ornamental Tarantula Bites That Responded Well to Intravenous Calcium Gluconate Treatment. Cureus. https://pubmed.ncbi.nlm.nih.gov/37692640/ Tarantulas: eight-legged pharmacists and combinatorial chemists. https://pubmed.ncbi.nlm.nih.gov/15066413/ Animal Venom Peptides as a Treasure Trove for New Therapeutics Against Neurodegenerative Disorders. https://pubmed.ncbi.nlm.nih.gov/30378475/ Urticaria caused by tarantula hairs. https://pubmed.ncbi.nlm.nih.gov/4684884/ The optical imaging of tarantula hair corneal injury: One case report and review of the literature. https://pubmed.ncbi.nlm.nih.gov/28736046/ “Spider bite” infections "Spider bite" lesions are usually diagnosed as skin and soft-tissue infections. https://pubmed.ncbi.nlm.nih.gov/19939602/ A clone of methicillin-resistant Staphylococcus aureus among professional football players. https://pubmed.ncbi.nlm.nih.gov/15689585/ Treatment of spider venom-associated muscle cramps Muscle spasms - A common symptom following theraphosid spider bites? https://pubmed.ncbi.nlm.nih.gov/33493497/ Differential block of sodium and calcium channels by chlorpromazine in mouse neuroblastoma cells. https://pubmed.ncbi.nlm.nih.gov/2157837/ Chlorpromazine (thorazine) in the treatment of intractable hiccups. https://pubmed.ncbi.nlm.nih.gov/13221413/ Chlorpromazine in the treatment of stubborn hiccup. https://pubmed.ncbi.nlm.nih.gov/14374117/ Pharmacologic Interventions for Intractable and Persistent Hiccups: A Systematic Review. https://pubmed.ncbi.nlm.nih.gov/29079070/

Season 2 Intro

Welcome back to Medical Rewrites. Let’s call this Season 2. That makes the unplanned sabbatical from last year feel purposeful. At the time of launching the podcast last Summer, I had written several episodes and had what I thought was a lot of runway. I was able to continue to write during the Fall semester. But when Spring semester hit, I was in the weeds. The other parts of my job like teaching and patient care are my priorities and they get the best version of myself. The podcast got the left overs. The writing felt burdensome and the creativity was inadequate. So I sacrificed the podcast until I was ready to write again. Which was this summer. I went to my Grandparents cabin, sat on the porch – which is the best spot to be able to steal wifi from the neighbors – I started writing again and made a plan for the year. This is the plan: episodes will be released every 4 weeks. There are bonus episodes as well but those dates have not been finalized. Thank you for your patience. Thank you for keeping Medical Rewrites in your podcast rotation. I hope you find lots of clinical pearls because I have been shucking a lot of oysters.

Temporada 1

Trainwreck

The rewrite today is for Trainwreck. The deep dive is about drug-drug interactions between alcohol and antibiotics. Movie suggestion form: https://tinyurl.com/8pa8svey References used in this episode Fact versus Fiction: a Review of the Evidence behind Alcohol and Antibiotic Interactions https://pubmed.ncbi.nlm.nih.gov/31871085/  Doxycycline PK after whiskey or wine https://pubmed.ncbi.nlm.nih.gov/7113712/   Doxycycline + rifampin for Brucellosis infection in rats fed alcohol https://pubmed.ncbi.nlm.nih.gov/16323439/   Doxycycline + rifampin PK changes in human Brucellosis infections https://www.ncbi.nlm.nih.gov/pmc/articles/PMC188288/      Long-term alcohol consumption and half-life of erythromycin and doxycycline https://pubmed.ncbi.nlm.nih.gov/1002368/   Tyramine concentrations in alcohol https://pubmed.ncbi.nlm.nih.gov/28824206/, https://pubmed.ncbi.nlm.nih.gov/34655830/   Linezolid and tyramine and increase in SBP https://pubmed.ncbi.nlm.nih.gov/11361052/                     Cephalosporin induced disulfiram-like reaction: a retrospective review of 78 cases. https://pubmed.ncbi.nlm.nih.gov/24670024/   Cephalosporin induced hypoprothrombinemia due to side chains of N-methylthiotetrazole (latamoxef, cefmenoxime, cefoperazone, cefotetan, cefamandole) https://pubmed.ncbi.nlm.nih.gov/3350995/    Metronidazole plus alcohol in rats https://pubmed.ncbi.nlm.nih.gov/10798595/  RCT metronidazole plus alcohol in humans https://pubmed.ncbi.nlm.nih.gov/12022894/  Retro case-control of pts admitted after ethanol who received metronidazole https://pubmed.ncbi.nlm.nih.gov/37494646/   Z-drugs adverse reactions https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8077048/  Zolpidem plus alcohol and ICU admission https://pubmed.ncbi.nlm.nih.gov/20458214/ 

Knives Out

The rewrite today is for Knives Out. The deep dive is about pain management of musculoskeletal injuries. Movie suggestion form: https://tinyurl.com/8pa8svey References used in this episode  Clinical Practice Guidelines for Pain Management in Acute Musculoskeletal Injury by the Orthopaedic Trauma Association Musculoskeletal Pain Task Force https://pubmed.ncbi.nlm.nih.gov/30681429/  Nonpharmacologic and Pharmacologic Management of Acute Pain From Non-Low Back, Musculoskeletal Injuries in Adults: A Clinical Guideline From the American College of Physicians and American Academy of Family Physicians INFOGRAPHIC INCLUDED https://pubmed.ncbi.nlm.nih.gov/32805126/  Oxycodone vs ibuprofen vs. combo tx for the treatment of pain after abdominal or pelvic surgery in women RCT https://pubmed.ncbi.nlm.nih.gov/15763605/  RCT topical diclofenac/menthol vs. placebo for ankle sprain pain https://pubmed.ncbi.nlm.nih.gov/28345425/  RCT topical diclofenac gel, ibuprofen gel, and ibuprofen gel with levomenthol for musculoskeletal injuries https://pubmed.ncbi.nlm.nih.gov/31353997/  RCT: ketorolac 60 mg IM vs ibuprofen 800 mg PO for acute musculoskeletal pain https://pubmed.ncbi.nlm.nih.gov/7618770/  RCT: ketorolac 60 mg vs 15 mg for acute musculoskeletal pain https://pubmed.ncbi.nlm.nih.gov/34365063/  Post-market surveillance study of ketorolac and GI bleeds https://pubmed.ncbi.nlm.nih.gov/8569017/  Nested-case control for NSAID-associated heart failure admissions https://pubmed.ncbi.nlm.nih.gov/27682515/  Drug Information summary about ketorolac duration by Christie Denton, PharmD, BCPS https://dig.pharmacy.uic.edu/faqs/2022-2/september-2022-faqs/what-evidence-is-there-for-the-5-day-maximum-with-the-use-of-ketorolac/

Knocked Up

Our medical rewrite today will be for Knocked Up. The deep dive will be about flatulence and conjunctivitis. Movie suggestion form: https://tinyurl.com/8pa8svey References used in this episode  Frequency of eye-related problems see in primary care https://pubmed.ncbi.nlm.nih.gov/1936738/  Microbiology of conjunctivitis https://pubmed.ncbi.nlm.nih.gov/24150468/ https://pubmed.ncbi.nlm.nih.gov/28535396/ https://pubmed.ncbi.nlm.nih.gov/1936738/ https://pubmed.ncbi.nlm.nih.gov/28499285/  Systematic review of signs and symptoms between viral and bacterial conjunctivitis https://pubmed.ncbi.nlm.nih.gov/35699701/  Research about gaseous components of farts https://pubmed.ncbi.nlm.nih.gov/18128419/ https://pubmed.ncbi.nlm.nih.gov/32900799/ https://pubmed.ncbi.nlm.nih.gov/31520080/ https://pubmed.ncbi.nlm.nih.gov/24150797/  Story about farting on a blood agar plate https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1121900/ https://www.abc.net.au/science/k2/homework/s312551.htm  Rectal colonization of GAS by physician and post-partum outbreak https://pubmed.ncbi.nlm.nih.gov/1928189/  Virome review https://pubmed.ncbi.nlm.nih.gov/35753153/  Postulating about SARS-CoV-2 spread through farts https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7716952/

28 Days

Our medical rewrite today will be for 28 Days. The deep dive will be about medical management of alcohol use disorder. Movie suggestion form: https://tinyurl.com/8pa8svey References used in this episode Mechanisms of medications used for alcohol use disorder https://pubmed.ncbi.nlm.nih.gov/35133639/ LiverTox of disulfiram https://www.ncbi.nlm.nih.gov/books/NBK548103/ COMBINE study comparing naltrexone vs. acamprosate and medication management vs. cognitive behavior intervention https://pubmed.ncbi.nlm.nih.gov/16670409/ Meta-analysis of naltrexone and acamprosate for alcohol use disorder https://pubmed.ncbi.nlm.nih.gov/24825644/ Meta-analysis of long-acting naltrexone injection vs placebo https://pubmed.ncbi.nlm.nih.gov/34033183/ CYP2D6 Overview https://www.ncbi.nlm.nih.gov/books/NBK574601/ Hydrocodone pain control in CYP2D6 slow metabolizers https://pubmed.ncbi.nlm.nih.gov/34423496/ Systematic review of naltrexone efficacy in women with alcohol use disorder https://pubmed.ncbi.nlm.nih.gov/28247556/ Sex differences and opioid use https://pubmed.ncbi.nlm.nih.gov/24508560/ Review on sex/hormone differences and opioid effects https://pubmed.ncbi.nlm.nih.gov/34995646/ Acamprosate efficacy based on sex https://pubmed.ncbi.nlm.nih.gov/21895717/

CODA

Our medical rewrite today will be for CODA. The deep dives will be about Dermatophyte infections – aka ring worm. Movie suggestion form: https://tinyurl.com/8pa8svey References used in this episode  Epidemiology and etiology of tinea infections· https://pubmed.ncbi.nlm.nih.gov/18478365/· https://pubmed.ncbi.nlm.nih.gov/33900539/· https://pubmed.ncbi.nlm.nih.gov/15097959/  Large case series of tinea scrotum https://pubmed.ncbi.nlm.nih.gov/37072674/  Effects of temperature and humidity on penetration of dermatophytes into human stratum https://pubmed.ncbi.nlm.nih.gov/14615792/  Tinea infections transmitted from sexual contact – MUST SEE PICTURES TO APPRECIATE SEVERITY· https://pubmed.ncbi.nlm.nih.gov/11913763/· https://pubmed.ncbi.nlm.nih.gov/26071391/· https://pubmed.ncbi.nlm.nih.gov/37347803/  British Association of Dermatologists' guidelines for the management of onychomycosis https://pubmed.ncbi.nlm.nih.gov/25409999/  UpToDate Dermatophyte infections https://www.uptodate.com/contents/dermatophyte-tinea-infections#H1217398057  Cochrane review of topical antifungal treatments for tinea cruris and tinea corporis https://pubmed.ncbi.nlm.nih.gov/25090020/  Superficial fungal infection review out of Australia from 2019 https://pubmed.ncbi.nlm.nih.gov/31569324/

Wedding Crashers

The medical rewrite today is for Wedding Crashers. The deep dives will be about tetrahydrozoline, an active ingredient in eye drops and sugar alcohols. Please note that this podcast discusses the poisoning found in the movie Wedding Crashers. Movie suggestion form: https://tinyurl.com/8pa8svey References  Systemic absorption after topical administration of tetrahydrozoline https://pubmed.ncbi.nlm.nih.gov/21972870/  Alpha 2 agonism on the GI track https://pubmed.ncbi.nlm.nih.gov/6148675/  Absolutely wild toxicology study of tetrahydrozoline in 19 infants from 1956 https://pubmed.ncbi.nlm.nih.gov/13295960/  Case report and of CV toxicity after oral tetrahydrozoline https://pubmed.ncbi.nlm.nih.gov/15388224/  Tetrahydrozoline toxicity review of the literature https://pubmed.ncbi.nlm.nih.gov/24760708/  Use of tetrahydrozoline in sexual assault · https://pubmed.ncbi.nlm.nih.gov/22554870/ · https://pubmed.ncbi.nlm.nih.gov/37278617/  Incredible reviews of Haribo Gummy Bears made with maltitol https://www.buzzfeednews.com/article/michaelrusch/haribo-gummy-bear-reviews-on-amazon-are-the-most-insane-thin  Diarrhea dose finding study in adult males https://pubmed.ncbi.nlm.nih.gov/12548293/  Diarrhea dose finding study in adult females https://pubmed.ncbi.nlm.nih.gov/18797153/  Maltitol organic chemistry – making it a solution https://pubmed.ncbi.nlm.nih.gov/32698373/

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