Aqua Tofana was a clear, nearly tasteless poison sold to women in 17th-century Italy. Linked to Giulia Tofana and later Geronima Spana, it became the center of a deadly Roman poisoning scandal involving abused wives, wealthy noblewomen, secret couriers, and papal investigators.

This episode follows the rise of the Aqua Tofana poison network, the 1659 Spana prosecution, the executions at Campo de’ Fiori, and the legends that later distorted the case. We also examine how marriage laws, class, gender, and the plague helped the poison spread through Rome.

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