In this episode of The Differential, Dr. Assem Al Refaei unpacks the physiology, pathologies, and diagnostic approach to adrenal gland disorders. Centered on high-yield Step 2 CK concepts and real-world clinical insights, we explore the mechanisms of adrenal hormone production, common disorders like adrenal insufficiency, Cushing syndrome, Conn syndrome, and pheochromocytoma, and the diagnostic steps using hormonal assays, suppression tests, and imaging. With a focus on recognizing clinical patterns and mastering diagnostic algorithms, this episode offers essential tools for understanding adrenal pathologies and excelling in exams and practice.