In this episode of The Differential, Dr. Assem Al Refaei presents a structured approach to diagnosing bleeding disorders. With a focus on high-yield concepts for Step 2 CK and practical clinical applications, we delve into identifying the underlying causes of bleeding based on clinical patterns, laboratory findings, and key physical exam clues. The discussion covers essential topics, including ITP, TTP, HUS, DIC, and qualitative platelet disorders such as von Willebrand disease (vWD), Bernard-Soulier syndrome, and Glanzmann thrombasthenia, along with other important conditions.