I read from downspout to downward.

Thank you very much to the woman and her daughter that I mentioned in the show. I'm very grateful for that very personal information they were willing to share. 

The earliest known case of Down syndrome is from about 1500 years ago!

https://www.science.org/content/article/oldest-case-down-syndrome-unearthed

The word of the episode is "Down syndrome".

https://en.wikipedia.org/wiki/Down_syndrome

https://ndss.org/about ...