In this episode of The Bone Health Basement Tapes, we sit down with Dr. Sundeep Khosla — endocrinologist, researcher, and one of the central scientific figures in modern bone health. Dr. Khosla has spent his career at the Mayo Clinic asking foundational questions about why the skeleton ages and fails, and his answers helped change how the field thinks about bone loss in both women and men. His research on sex steroids and skeletal aging revealed that estrogen is not just a female story — it plays a quiet but decisive role in male bone health as well, a finding that reshaped clinical thinking and opened new lines of research.

In this conversation, we trace the arc of that scientific journey: how skeletal biology evolved from descriptive observation into molecular and ...