Can a dissociative drug create the mental breathing room needed to break a decade-long cycle of severe methamphetamine addiction? In this episode of the Talking Ketamine podcast, we explore the groundbreaking KAPPA pilot trial detailed in the qualitative study, 'Navigating ‘k-land’: a qualitative exploration of participants’ experiences of ketamine-assisted psychotherapy for methamphetamine use disorder' by Fletcher et al. The study follows 14 individuals struggling with severe methamphetamine use disorder (MAUD)—many of whom had faced years of chronic treatment failure and deep societal stigma—as they undergo a novel clinical intervention combining subanesthetic ketamine infusions with cognitive behavioral therapy (CBT).

For individuals with a history of chronic methamphetamine use, everyday life feels like being stuck on a broken treadmil ...