Norepinephrine (Levophed) 80/20 Summary

• Action & MOA: Direct α-agonist causing potent vasoconstriction. Modest β1​ activity triggers cardiac stimulation at lower doses; vasoconstriction dominates at higher doses. Elevated SVR triggers reflex vagal bradycardia (slowing HR). Coronary flow increases without raising myocardial oxygen demand.
• Uses: First-line for septic shock, sepsis, acute hypotension, cardiogenic shock. Alternative in hepatorenal syndrome (with albumin).
• Complications: Tissue necrosis (extravasation), bradycardia, lactic acidosis,  ...