1. Medication Name/Class Trilafon (perphenazine). Class: First-Generation Antipsychotic (FGA); Phenothiazine Antiemetic.

2. Mechanism of Action Blocks postsynaptic dopamine D2 receptors in the mesolimbic system (reducing psychosis) and the chemoreceptor trigger zone (stopping emesis). It also causes alpha-1 adrenergic and moderate anticholinergic blockade.

3. Expected Action/Therapeutic Effect Decreased psychotic symptoms and resolution of severe nausea or vomiting.

4. Indications Common: Schizophrenia, severe nausea and vomiting. Off-Label: Severe behavioral or psychological symptoms of dementia (BPSD).

5. Pharmacokinetics Extensively metabolized in the liver (CYP2D6); contraindicated in significant hepatic impairment. I ...