PHARM | TCAs Amitriptyline
STAT Stitch Deep Dive Podcast Beyond The Bedside by Regular Guy
Episode notes
đź’Š PHARM STUDY GUIDE: AMITRIPTYLINE (Elavil) Class: Tricyclic Antidepressant (TCA)
🧠MOA (80/20): Blocks neuronal reuptake of serotonin & norepinephrine; also anticholinergic, antihistamine, and sodium-channel effects → efficacy + side-effect burden. NCBI
📋 Indications (what you’ll actually see):
- Major depressive disorder
- Off-label, low dose: neuropathic pain, migraine prevention, insomnia (sedating).
⚠️ Red-Flag Side Effects (Prioritize 🚨):
- Cardiac toxicity – QT prolongation, conduction b ...Â
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