PHARM | Azithromycin

STAT Stitch Deep Dive Podcast Beyond The Bedside by Regular Guy

S03
30:14
Episode notes

Everything Azithromycin.

1️⃣ Azithromycin (Zithromax, Zmax)

Class: Macrolide antibiotic (50S inhibitor). MOA: Inhibits bacterial protein synthesis → bacteriostatic/cidal by concentration. Use: Respiratory infections (strep pharyngitis, pneumonia), STIs (gonorrhea, chancroid), and MAC prophylaxis in advanced HIV. Contra: Hypersensitivity, prior cholestatic jaundice, QT prolongation, hypokalemia, or bradycardia → risk of Torsades de Pointes. Adverse / Interventions:

  • QT Prolongation / Arrhythmia: Monitor cardiac status; avoid QT-prolonging drugs (quinidine, amiodarone).
  • Hepatotoxicity / Cholestasis: Monitor LFTs (AST, ALT, LDH).
  • SJS / TEN / Anaphylaxis:
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