Swine Disease Reporting System (SDRS) Report 55, Published September 6th, 2022. In this episode, we shared aggregate data from participating veterinary diagnostic laboratories (VDLs) in the United States of America until August 2022. In today`s episode, we invited Dr. Jianqiang Zhang (Iowa State University) for an important discussion about PRRSV isolation, comparison of PRRSV sequences from virus isolates versus clinical samples, and updates on clinical consequences of PRRSV 1-4-4 L1C variant infection.