In this episode of Lion’s Digest – Advances in GI and Hepatology, Dr. Matthew Coates sits down with Dr. Prashant Nighot to explore the intricate biology of autophagy, intestinal permeability, and tight junction regulation—and how these processes shape gastrointestinal and liver health.

Dr. Nighot shares his expertise on how autophagy, the cell’s internal recycling and quality-control system, plays a critical role in maintaining epithelial integrity and barrier function. The discussion highlights how disruptions in autophagy can lead to increased gut permeability (“leaky gut”), altered tight junction dynamics, and downstream inflammation.

The conversation dives into the translational relevance of this work, focusing o ...