This episode equips psychiatric nurse practitioners with advanced strategies for managing complex withdrawal syndromes and identifying medical mimics in clinical practice. Listeners will explore evidence-based protocols for treating buprenorphine-precipitated withdrawal—including the efficacy of administering additional buprenorphine—and review a novel inpatient pathway for methamphetamine withdrawal. We also dive into the diagnosis and management of Functional Neurological Disorder (FND), emphasizing the importance of identifying positive physical signs and providing clear patient education. Furthermore, the episode details how to distinguish psychiatric symptoms from medical conditions like anti-NMDA receptor encephalitis and acute intermittent porphyria to prevent misdiagnosis. Finally, we discuss practical interventions for akathisia, such as th ...