Cuban refugees Marina and Esteban reach Princeton-Plainsboro after three days adrift at sea, arriving with no medical records and a list of symptoms no doctor has been able to diagnose. With almost no baseline, House runs a blind differential that spirals into crisis when Marina's heart stops mid-angiogram while she remains conscious — leading to three hours of manual CPR, a failed bypass, a death declaration, and an inexplicable revival that House treats as diagnostic evidence rather than miracle. He performs a second angiogram and finds a congenital third coronary ostium, a surgically correctable anomaly that explains everything.

This is the Season 3 finale, and the medical case runs parallel to the team's collapse: Chase is fired without warning mid-episode, Foreman walks out after refusing every counteroffer, and Cameron quietly submits ...