Explore the fascinating world of pharmacokinetics (PK) in preclinical testing, where scientists unravel the mysteries of a drug's journey through the body. We focus on ADME studies—absorption, distribution, metabolism, and excretion—conducted in animal models, providing crucial insights for predicting human doses. This episode delves into the experimental techniques used to track a drug's movement and transformation within the body, and how this data is interpreted to project safe and effective doses for human trials. We'll also discuss the concept of bioavailability, which describes how much of the administered drug actually reaches the bloodstream, a crucial factor in determining the right dose and delivery method.

Furthermore, we'll explore how researchers use mathematical models and pharmacokinetic parameters to predict a drug's behavio ...