9 - Basics of Drug Manufacturing (S1E9)
From Concept to Medicine - A Comprehensive Drug Development ... by Jim Mitchell
Episode notes
From the laboratory flask to the large-scale manufacturing plant, this episode explores the intricate world of drug manufacturing. Discover the challenges of scaling up drug production, from synthesizing a few grams of a compound to producing kilograms or even tons while maintaining purity and maximizing yield. We'll discuss the complexities of process engineering, highlighting factors like mixing, heat transfer, and reaction kinetics that can significantly impact the final product. This episode also explores the role of enabling chemistry in optimizing drug synthesis and making it robust and reproducible at scale.
We'll delve into the importance of pilot plants in testing and refining the manufacturing process before full-scale production. Learn about the critical role of contract development and manufacturing organizations (CDMOs) in prov ...