This episode explores the pathogenesis, diagnosis, and treatment of diuretic-resistant ascites in cirrhosis, covering the comprehensive content from the UpToDate article, including the mechanisms behind diuretic resistance, diagnostic approaches, and advanced management strategies such as large-volume paracentesis and transjugular intrahepatic portosystemic shunt (TIPS). It provides residents with a practical guide to tackling this complex condition. The podcast occasionally concludes each subtopic with "if you can’t remember everything, remember this" to emphasize critical points for quick recall. Tune in to master the management of diuretic-resistant ascites in cirrhosis!